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Hashimoto’s thyroiditis worsens ovaries in polycystic ovary syndrome patients compared to anti-müllerian hormone levels

BMC Endocrine Disorders Mar 16, 2021

Serin AN, Birge O, Uysal A, et al. - Given the higher prevalence of Hashimoto’s Thyroiditis (HT) in polycystic ovary syndrome (PCOS) patients, researchers sought to determine ovarian reserve and investigated how autoimmune exposure time affects ovarian reserve in PCOS patients with HT by Anti-Müllerian hormone (AMH) levels. They included 46 PCOS patients and 46 PCOS with HT diagnosed patients in this study. Twenty patients (43.5%) and 8 (17.4%) patients in the PCOS group and the PCOS + HT group were fertile, respectively. PCOS + HT group had significantly lower fertility rate. Overall findings suggest that ovarian reserve is negatively affected by the coexistence of PCOS and HT. More exposure of the ovaries to autoantibodies can result in ovarian destruction, similar to the thyroid gland like HT. In view of all these close relationships with PCOS and thyroid dysfunctions, they emphasize evaluation of both thyroid autoantibodies and hormone levels in PCOS patients at the first visit. More close monitoring is recommended for patients with PCOS + HT to determine the fertility treatment options and control premature ovarian failure table.

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