Zhou J, et al. - In this retrospective study, researchers examined the connection between haptoglobin (Hp) gene polymorphism and the severity of nonalcoholic fatty liver disease (NAFLD). The study sample consisted of 441 who had their clinical biochemical parameters measured. The investigators conducted haptoglobin genotyping via genomic DNA extracted from peripheral blood leukocytes. They found that patients with NAFLD had a much lower Hp 1-1 genotype frequency and a higher Hp 2-2 frequency vs healthy controls. Hp 2-2 genotype NAFLD patients had much higher levels of body mass index, total cholesterol, liver enzymes, ferritin, and controlled attenuation parameter values vs non-Hp 2-2 genotype. The authors, thus, suggested that Hp 2-2 genotype may be closely linked to NAFLD severity.