Li S, et al. - Herein, the authors investigated the connection of handgrip strength with measures of insulin resistance (fasting insulin and homeostasis model assessment of insulin resistance [HOMA-IR]) and glucose metabolism (fasting and 2-hour glucose levels), in adolescents from the National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. The yielded results shed light on the correlation between muscular fitness, measured by handgrip strength, with insulin resistance and glucose metabolism in adolescents. This data indicated that increasing muscular fitness could display beneficial effects for the early prevention of insulin resistance and type 2 diabetes.