Barbateskovic M, Krauss SR, Collet MO, et al. - By performing a systematic review with meta-analysis and Trial Sequential Analysis of relevant randomized clinical trials (RCTs), researchers examined the influences of haloperidol in critically ill patients experiencing delirium. They analyzed RCTs evaluating the impacts of haloperidol, compared with any intervention, on all-cause mortality, serious adverse reactions/events, days alive without delirium, health-related quality of life, cognitive function and delirium severity among critically ill patients having delirium. Overall 8 RCTs including 11 comparisons (n = 951) were analyzed. In 3 trials, rescue haloperidol was used; eliminating these, an influence of haloperidol vs control on all-cause death or delirium severity was not found. Only sparse and low quality and inconclusive evidence were found for the use of haloperidol to manage critically ill patients with delirium. Thus, no certainty was gained for any beneficial, harmful or neutral impacts of haloperidol in these patients.