Maiden MJ, et al. - In this retrospective cohort study, researchers investigated the link between the changes in haemoglobin concentration and the volume of intravenous fluids administered during resuscitation from septic shock, using univariate and multivariate analysis, in patients enrolled in the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial who were not transfused red blood cells. The observed median (IQR) haemoglobin concentration at baseline was 133 (118–146) g/L, which was seen to decline to 115 (102–127) g/L within the first 6 h of resuscitation, 110 (99–122) g/L after 24 h, and 109 (97–121) g/L after 72 h. During resuscitation from septic shock, a decrease in haemoglobin concentration was observed, which showed a significant but weak association with the volume of intravenous fluids administered.