Obokata M, et al. - Researchers analyzed the links between simultaneously measured central haemodynamics, symptoms, and lung ventilatory and gas exchange abnormalities during exercise in heart failure with preserved ejection fraction (HFpEF). Study participants included subjects with invasively-proven HFpEF and non-cardiac causes of dyspnoea who underwent cardiac catheterization at rest and during exercise with simultaneous expired gas analysis. This investigation offers the first evidence linking altered exercise haemodynamics to pulmonary abnormalities and symptoms of dyspnoea in patients with HFpEF.