Sims TT, Colbert LE, Zheng J, et al. - Among women with locally advanced cervical cancer, this investigation was undertaken to characterize variation in the gut microbiome and to contrast it to healthy controls. This study included 42 cervical cancer patients and 46 healthy female controls, in whom, characterization of the 16S rDNA fecal microbiome was performed. A positive correlation of bacterial alpha diversity with age in cervical cancer patients and its inverse link in controls was observed. Cervical cancer patients vs controls had significantly higher alpha diversity, though limitation of this link to older women (> 50 years) was suggested by stratification by age. Significant enrichment of Prevotella, Porphyromonas, and Dialister in cervical cancer patients and of Bacteroides, Alistipes and members of the Lachnospiracea family in healthy people was observed. Overall, cervical cancer patients and controls had different gut microbiota diversity and composition. Etiologic/clinical disparities may be indicated by links within the gut microbiome by age.