GSG2 promotes development and predicts poor prognosis of ovarian cancer
Cancer Management and Research Jan 21, 2021
Huang Y, Liu Y, Zhu K, et al. - Researchers sought to determine the role of GSG2 (also known as Haspin) in ovarian cancer. They investigated GSG2 expression in ovarian cancer tissues and corresponding normal tissues, using immunohistochemical analysis. They assessed the link between GSG2 and tumor features as well as prognosis. They found GSG2 was upregulated in ovarian cancer, and its expression was found to be positively associated with tumor grade and AJCC stage and negatively correlated with the prognosis. Moreover, ovarian cancer development was inhibited by knockdown of GSG2, via cell growth suppression and inducing cell apoptosis. Overall, findings showed the involvement of GSG2 in ovarian cancer development as well as its potential to serve as a treatment target and prognostic indicator in ovarian cancer treatment.
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