Rosenberg AGW, De Gouveia Buff Passone C, Pellikaan K, et al. - Since growth hormone treatment (GHt) improves physical health and cognition in children with Prader-Willi syndrome (PWS), researchers provided an overview of current knowledge on GHt in PWS adults. Data on body composition, BMI, cardiovascular endpoints, bone, cognitive function, quality of life, and safety have been extracted. Nine randomized controlled trials and 20 non-randomized (un)controlled trials were involved. In adults with PWS, GHt seems to be safe and to improve body composition. Because poor body composition has been linked to an increased risk of cardiovascular morbidity in adults with PWS, improving body composition may decrease cardiovascular complications in this vulnerable patient group.