Butler G, et al. - For the comparison of health-related quality of life (HRQOL) in children on growth hormone treatment (GHT) for isolated or multiple GH deficiency (IGHD), acquired GH deficiency (AGHD) and Turner syndrome (TS) vs untreated short stature controls, researchers conducted a study in 18 UK centers. Participants were children and adolescents 6-16 years with IGHD (n=73) and AGHD (n=45), and 22 girls with TS. While HRQOL seemed to be improving with GHT, patients with short stature due to GHD have lower functioning than controls. The absolute and independent effect of GHT was not established by researchers. For the determination of whether children should receive GHT, HRQOL should not be considered a primary measure, as with adults.