Shemesh-Iron M, et al. - In this four-year intervention study [one-year double-blinded, randomized, placebo-controlled (growth hormone (GH)/placebo-2:1) and three-year open-labeled GH-therapy], the impact of GH therapy on psychosocial well-being and the ability of psychological metrics to define short stature-related distress were determined by researchers. The study finding of improved psychosocial functioning only in the GH-treated boys after one-year blinded intervention indicated that it was GH therapy, instead of being enrolled in a clinical trial, which contributed to the result. Long-term open-label GH treatment significantly improved the perception of height and self-esteem.