Sueishi T, Akasaki Y, Goto N, et al. - G protein-coupled receptor kinase 5 (GRK5) expression in human normal and OA knee joints was investigated immunohistochemically in order to examine the functional involvement of GRK5 in OA pathogenesis. Gain- or loss-of-function experiments were carried out using human and mouse chondrocytes. In this study, results suggested that cartilage degradation was regulated by GRK5 through a catabolic response mediated by NF-κB signalling, and it is, hence, a possible target for OA treatment. Moreover, amlexanox could be a significant compound in the appropriate drugs.