Sampedro F, Roldán A, Alonso-Solís A, et al. - Researchers sought to describe structural brain changes in schizophrenia (SCZ) patients with treatment-resistant auditory verbal hallucinations (TRAVH). Cortical thickness and subcortical volumetric data were studied for macrostructural grey matter changes in SCZ patients with TRAVH (n = 29), both with respect to non-hallucinating (n = 20) patients and healthy controls (n = 27). Per findings, key brain regions such as the ventral ACC, the NAcc and the hippocampus, exhibit a microstructural–rather than a macrostructural–compromise. They illustrated that microstructural imaging biomarkers have a potential role in SCZ. Notably, these biomarkers are suggested to be valuable for both detection and monitoring subtle grey matter changes in critical brain regions such as deep brain stimulation targets. In addition, results indicated the presence of a more aggressive and active pathological mechanism in cases with TRAVH, yielding new insight into the etiology of this debilitating illness.