Chia DKA, et al. – For patients with unresectable liver tumors due to insufficient future liver remnant (FLR), associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) and conventional staged hepatectomy (CSH) were the options. Researchers compared the two procedure regarding induction of hypertrophy. They identified that ALPPS was superior in inducing FLR growth but associated with increased post–hepatectomy liver failure compared to CSH.

Methods

• Researchers performed a retrospective comparison of clinical data, liver volumetry and surgical outcomes between 10 ALPPS and 29 CSH patients.

Results

• The groups were similar regarding patient demographics and disease characteristics.
• Superior FLR growth was observed with ALPPS (ALPPS vs. CSH, 48.1% (IQR 39.4–96.9%) vs. 11.8% (IQR 4.3–41.9%), p = 0.013).
• However, the ALPPS group indicated higher post–operative day 5 international normalized ratio (INR) (ALPPS vs. CSH, 1.6 (IQR 1.5–1.8) vs. 1.4 (IQR 1.3–1.6), p = 0.015) and rate of post–hepatectomy liver failure (ALPPS vs. CSH, 25 vs. 0%, p = 0.032).
• The groups were simialr regarding 90–day mortality (ALPPS vs. CSH, 12.5% vs. 0%, p = 0.320).