Radetz A, Koirala N, Krämer J, et al. - MRI data from 83 individuals with clinically isolated syndrome and early relapsing–remitting Multiple sclerosis (MS, a chronic inflammatory and neurodegenerative disease resulting in gray matter atrophy and brain network reconfiguration as a response to progressing tissue damage) were obtained at two time points with a follow-up following 1 year in order to assess whether white matter network reconfiguration seemed following gray matter damage, or whether the gray matter degenerated after modifications in white matter networks. It was discovered that atrophy of deep gray matter structures drives the adaptation of white matter networks. Furthermore, for disability progression and cognitive performance, it was found that deep gray matter volumes are highly predictive.