Imber BS, et al. - Because very low dose radiotherapy (4Gy; VLDRT) has been shown to be an efficient treatment for low-grade (1-2) follicular lymphoma (FL) and provides the benefit of a shorter course and better side effect profile compared to full dose RT regimens (24 Gy), researchers evaluated the results of a pilot cohort of VLDRT-treated patients with grade 3A FL. Nine consecutive patients (78% female) with median age of 70 years (range 52-92) who received 2 Gy x 2 fractions for grade 3A FL between 2010-2018 were analyzed. Findings revealed that this is the first reported series of patients with high grade FL treated with VLDRT. According to outcomes, grade 3A FL behaves similarly to low grade disease, showing outstanding radiographic responses and local control to only 4 Gy. In patients with higher-grade FL, these findings support an expanded evaluation of VLDRT.