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Glycated hemoglobin correlates with arterial stiffness and endothelial dysfunction in patients with resistant hypertension and uncontrolled diabetes mellitus

The Journal of Clinical Hypertension May 11, 2018

Moreno B, et al. - In patients with resistant hypertension (RHTN), researchers assessed the impacts of glycated hemoglobin (HbA1c) on flow-mediated dilation, intima-media thickness, pulse wave velocity, and left ventricular mass index in those having RHTN–controlled diabetes mellitus (HbA1c <7.0%) vs those with RHTN–uncontrolled type 2 diabetes mellitus (HbA1c ≥7.0%). Patients with RHTN–uncontrolled diabetes mellitus were found to have worse endothelial dysfunction and arterial stiffness. Both the groups had similar intima-media thickness and left ventricular mass index measurements. Overall, the grade of arterial stiffness and endothelial dysfunction in patients with RHTN could be predicted by HbA1c, and comorbid uncontrolled diabetes mellitus implicates further impairment of vascular function.

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