Punnose J, et al. - Researchers conducted this retrospective cohort study to evaluate the effectiveness of first-trimester glycated hemoglobin (HbA1c-FT) in diagnosing or anticipating gestational diabetes mellitus (GDM), defined as glucose intolerance resulting in hyperglycaemia with variable severity and onset during pregnancy, in Asian Indian women. The sample consisted of 2,275 women who had both HbA1c-FT estimation and GDM screening with a one-step 75 g oral glucose tolerance test. In order to assess the independent impact of HbA1c-FT on GDM diagnosis, a multivariable logistic regression analysis after adjusting for plausible confounders was used. In Asian Indian women, HbA1c-FT is an independent GDM predictor but lacks sufficient sensitivity or specificity for use as a diagnostic test.