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Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients

Clinical Nutrition Aug 23, 2018

Doola R, et al. - Experts aspired to explore whether glycaemic variability [defined as the coefficient of variation (GV)] was associated with an increase in mortality. In addition, they reviewed any factors affecting glycaemic variability, and to identify the role nutrition, especially carbohydrate, plays as a contributing factor to glycaemic variability and other clinical outcomes (duration of ventilation and intensive care unit {ICU} length of stay). No effect of any nutritional factor on glycaemic variability was found. Findings suggested an association of GV with excess mortality. They found that administration of increasing doses of insulin was related to increased GV. It was noted that increased carbohydrate intake was correlated with an increased insulin requirement, and additionally increased the duration of mechanical ventilation and ICU length of stay.
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