Titan SM, et al. - The association of GlycA with albuminuria and estimated glomerular filtration rate (eGFR) was assessed in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Findings demonstrated an association of GlycA with albuminuria and eGFR, independently of major risk factors for chronic kidney disease (CKD) progression, including (and with a stronger association than) high-sensitivity C reactive protein (hsCRP).

Methods

• Researchers performed this study in 5050 participants.
• Among study participants, they assessed the cross-sectional link between GlycA (automated NMR LipoProfile(®) test spectra, LabCorp, Raleigh, NC), and overnight 12 h–albuminuria and CKD-EPI eGFR.

Results

• Findings demonstrated that higher GlycA was reported among older, women, smokers, alcohol abstemious, obese and in those with diabetes, hypertension or dyslipidemia.
• Researchers noted that both eGFR and albuminuria were associated to GlycA.
• In linear regression, even after adjustments including hsCRP, an independent association of GlycA with log albuminuria (B 0.03; 95%CI 0.02–0.04, P < 0.0001, per 1sd increase) and inverse association with eGFR (B -0.53; 95%CI -0.99 – -0.07, P < 0.02) was reported.
• An independent relation of GlycA to the risk of A2 or A3 albuminuria (OR 1.42, 95%CI 1.27–1.57, p < 0.0001, per 1sd increase), of having an eGFR < 60 ml/min/1.73m² (OR 1.26, 95%CI 1.12–1.41, p=0.0003, per 1 sd) or of a combined diagnosis of both conditions (OR 1.35, 95%CI 1.23–1.46, p < 0.0001, per 1 sd) was highlighted in logistic regression.
• In addition, researchers found that in the ROC curve, GlycA had a higher AUC in comparison to hsCRP (AUC 0.67 vs 0.62, p=0.06) for the association with albuminuria A2 or A3.