Wang QL, et al. - Incidence data for esophageal squamous cell carcinoma (ESCC) were gathered from 30 well-established cancer registries from 20 countries in Europe, Northern America, Australia, or Asia for 1970–2015 in order to provide an update of the global temporal trends in the incidence of ESCC. Using joinpoint analysis and log-linear regression, time trends in annual age-standardized incidence rates of ESCC were evaluated. It was noted that the global ESCC incidence has decreased over time in men whereas the incidence trends vary across populations, and the rates have increased in some countries in women. Findings suggested that changes in the prevalence of tobacco smoking and alcohol consumption might have contributed to these time trends.