Chiumello D, Umbrello M, Sferrazza Papa GF, et al. - In this prospective, observational study involving 32 sedated, paralyzed acute respiratory distress syndrome patients (age 65 ± 14 yr, BMI 25.9 ± 6.5 kg/m², and Pao₂/Fio₂ 139 ± 47), researchers compared the global and regional diagnostic accuracy of lung ultrasound and CT scan. They performed lung CT scan and lung ultrasound at positive end-expiratory pressure 5 cm H₂O. Data reported that global agreement between lung ultrasound and CT ranged from 0.640 to 0.934 and was on average 0.775. The authors discovered that the overall sensitivity and specificity of lung ultrasound ranged from 82.7% to 92.3% and from 90.2% to 98.6%, respectively. Lung ultrasound is a reproducible, sensitive and specific tool that allows the identification of morphological patterns on the bedside in acute respiratory distress syndrome. The presence of deep lung changes can affect this technique's diagnostic performance.