Haffner MC, et al. - The present study was undertaken to investigate the relationship between the cribriform pattern on biopsies and pathological findings on subsequent prostatectomies. Researchers conducted a prospective cohort including a total of 367 men between 2014 to 2018 treated at a single institution. In this study, the presence of cribriform morphology on biopsies was compared with clinicopathological findings on matched radical prostatectomy specimens. The results showed that the cribriform architecture was present in 63.5% of all biopsies and was correlated with the overall extent of Gleason pattern 4. This large prospective study analyzing biopsy and prostatectomy finding of cribriform architecture shows that cribriform pattern 4 is correlated with adverse prognostic features and indicates the relevance for recognizing specific morphologies with distinct biological and clinical features.