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GES: A validated simple score to predict the risk of HCC in patients with HCV‐GT4‐associated advanced liver fibrosis after oral antivirals

Liver International Nov 02, 2020

Shiha G, Waked I, Soliman R, et al. - This study was intended to construct a score that offers individualized patient hepatocellular carcinoma (HCC) risk prediction. Researchers performed a two‐centre prospective study including a total of 4,400 patients, with cirrhosis and advanced fibrosis who achieved a sustained virologic response (SVR), including 2,372 patients (derivation cohort). Researchers distinguished HCC‐associated factors by multivariable Cox regression analysis to develop a scoring model for prediction of HCC risk and subsequently internally and externally validated in two independent cohorts of 687 and 1,341 patients. For the development of HCC, GES score is simple with validated good predictive ability after eradication of HCV and may be beneficial for HCC risk stratification in those patients.

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