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Gentamicin containing collagen implants and groin wound infections in vascular surgery: A prospective randomised controlled multicentre trial

European Journal of Vascular and Endovascular Surgery Apr 11, 2020

Wübbeke LF, Telgenkamp B, van Boxtel T, et al. - Researchers investigated if gentamicin containing collagen implants could reduce surgical site infections (SSIs) in patients undergoing an inguinal incision for vascular surgery. At four hospitals in The Netherlands and Belgium, randomization of 288 patients who underwent an inguinal incision for primary arterial repair (femoral endarterectomy, femorofemoral or femoropopliteal bypass, aortobifemoral bypass, thrombectomy, embolectomy, endovascular aneurysm repair) was done to receive a gentamicin implant (study group) or no implant (control group). Outcomes of this prospective blinded randomized controlled multicenter trial revealed no significant overall reduction of SSIs in correlations with gentamicin implants. In high risk centers, gentamicin implants resulted in reduction of the incidence of SSIs and may be a valuable adjunct to improve outcomes in such vascular centers with a high incidence of wound infections.

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