Ross JDC, et al. - For treatment of gonorrhea, researchers evaluated the efficacy of gentamicin as a substitute for ceftriaxone (both combined with azithromycin). In this randomized non-inferiority trial, adults (aged 16-70 years) who had a diagnosis of uncomplicated genital, pharyngeal, or rectal gonorrhea were eligible for participation. A single intramuscular dose of either gentamicin 240 mg (gentamicin group) or ceftriaxone 500 mg (ceftriaxone group) was randomly assigned to the participants, along with a single 1 g dose of oral azithromycin. According to findings, while gentamicin is not suitable as a first-line treatment for gonorrhea, it could still be useful in patients with isolated genital infection or those with ceftriaxone allergy or intolerance or with ceftriaxone-resistant isolate.