Zheng F, et al. - Investigators examined the expression of 6-methyladenine (6mA) DNA and explained its gene regulation role in systemic lupus erythematosus (SLE) among 20 SLE cases and 20 normal control healthy individuals (HCs). They isolated genomic DNA from peripheral blood mononuclear cells and subsequently underwent 6mA-immunoprecipitation-sequencing (6mA-IP-Seq) after DNA quality control and 6mA precipitation. They classified 5462 hypermethylation and 431 hypomethylation genes in PBMCs of subjects with SLE, which showed the role of high level of 6mA in the pathogenesis of SLE. They implied regulation of the inflammatory process might be controlled by hypermethylation genes.