Kawamura Y, et al. - Through a first-ever genome-wide association study (GWAS) of 945 clinically defined gout cases and 1,003 asymptomatic hyperuricemia (AHUA) controls followed by 2 replication studies, experts recognized the novel gout loci that exacerbate AHUA into gout (one of the most common forms of inflammatory arthritis). At the genome-wide significance level, this new approach enabled the researchers to recognize two novel gout loci and one suggestive locus. The present study also recognized the loci of ABCG2, ALDH2, and SLC2A9. The rs671 of ALDH2 was recognized as a gout locus by GWAS for the first time. Three ‘gout vs AHUA GWAS’-specific loci were exhibited as clearly correlated with mechanisms of gout development which distinctly varied from the known gout risk loci that basically raised serum uric acid level, on contrasting overall survival for each locus in the present with the previous GWAS. Hence, this was the first to expose the loci correlated with crystal-induced inflammation, the last step in gout development that exacerbates AHUA into gout. In high-risk AHUA people, these conclusions should help to clarify the molecular mechanisms of gout development and aid the prevention of gout attacks.