Burton CL, Lemire M, Xiao B, et al. - Researchers sought to determine genetic variants linked with obsessive-compulsive (OC) traits and if OC traits and obsessive-compulsive disorder (OCD) shared genetic risk by utilizing a novel trait-based measure. Utilizing the Toronto Obsessive-Compulsive Scale (TOCS), a genome-wide association analysis (GWAS) of OC traits was conducted in 5,018 unrelated Caucasian children and adolescents from the community (Spit for Science sample). A locus tagged by rs7856850 in an intron of PTPRD (protein tyrosine phosphatase δ) was identified to be significantly linked with OC traits at the genome-wide significance level. In addition, a link of rs7856850 with OCD was noted in a meta-analysis of OCD case/control genome-wide datasets. A significant link of polygenic risk scores from OC traits with OCD was identified in case/control datasets and vice versa. OC traits were greatly, if not significantly, genetically correlated with OCD. In this study, they described the first confirmed genome-wide significant variant for OC traits in PTPRD, downstream of the most significant locus in a prior OCD GWAS. These findings support the feasibility and power of employing trait-based approaches in community samples for genetic discovery.