Greenwood TA, Lazzeroni LC, Maihofer AX, et al. - A total of 1,789 individuals with schizophrenia and healthy comparison participants (HCPs) of self-reported European or Latino ancestry were enrolled via a collaborative venture across the Consortium on the Genetics of Schizophrenia (COGS) sites and genotyped using the PsychChip in order to build on former evaluations of heritability, relationship, and connections in the COGS phase 1 (COGS-1) families by reporting a genome-wide association study of 11 schizophrenia-related endophenotypes in the independent phase 2 (COGS-2) cohort of individuals with schizophrenia and HCPs. In all, seven genome-wide important regions and two approximately vital regions containing various genes of interest, including NRG3 and HCN1, were recognized for seven endophenotypes. Enrichment analyses done at the level of P < 10−4, matched auspiciously with former relationship results in the COGS-1 families and exhibited comprehensive overlap with regions recognized for a schizophrenia diagnosis for each of the 11 endophenotypes. In conclusion, these analyses recognized various genomic regions of interest, needing further examination and confirmation. For resolving the genetic architecture of schizophrenia and identifying the underlying biological dysfunctions, these data appear to exhibit the use of endophenotypes. Moreover, in schizophrenia and related psychotic disorders, understanding the molecular basis of these endophenotypes could aid to recognize novel treatment targets and pave the route for precision-based medicine.