Blanc P, et al. - In this ancillary study from a prospective cohort, researchers investigated genetic components that predict persistent postsurgical neuropathic pain. This study was conducted at 18 French university hospitals with 561 patients who had scheduled surgery and were at risk of persistent postoperative pain (159 cases and 402 controls). They observed that only a single suggestive link was reached for a sole nucleotide polymorphism, ie, rs2286614 (selected to tag KCNK4) after correcting for type-I error inflation. TRAAK (a two-pore domain background K+ channel involved in the modulation of the primary thermoreceptors of the transient receptor potential channels family) is encoded by this gene. This is the first genetic association study addressing this topic.