Wang S, et al. - Data from a genome-wide association study (GWAS) of breast cancer was employed to investigate single-nucleotide polymorphisms (SNPs) in the vitamin D related pathway genes. As per findings, vitamin D status was not associated with breast cancer risk in women of African ancestry. This outcome indicated that vitamin D was unlikely to have significant effect on breast carcinogenesis. In addition, TYRP1 seemed to be related to breast cancer through a non-vitamin D relevant mechanism and warranted further studies.