Mu R, Liu H, Luo S, et al. - Researchers sought to determine whether and how 31,032 single nucleotide polymorphisms (SNPs) in 368 mitotic phase-related pathway genes were associated with overall survival (OS) of patients with non-small cell lung cancer (NSCLC). They found that CHEK1 rs76744140 T>C, PRIM2 rs6939623 G>T and CDK6 rs113181986 G>C were the three independent SNPs that were significantly related to NSCLC OS. The number of integrated unfavorable genotypes of these three SNPs was shown to be significantly related to NSCLC OS as well as disease-specific survival in the PLCO (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial) dataset. Additional analyses pointed out that NSCLC survival may be influenced by CHEK1, PRIM2 and CDK6. In the light of these findings, experts concluded that these genetic variants may serve as prognostic biomarkers of NSCLC patients.