Dahlin AM, et al. - Researchers performed genome-wide analyses to discover novel genetic variants associated with glioma risk in children and adolescents and young adults (AYA). From Sweden and Denmark, 854 patients diagnosed up to the age of 29 and 3689 controls were examined for the association between 8,831,628 genetic variants and risk of glioma. Performing detailed investigation of 41 established adult glioma risk variants, children and AYA displayed association of 3 adult glioma risk variants, rs634537, rs2157719, and rs145929329, all mapping to the 9p21.3 (CDKN2B-AS1) locus, with glioma risk. rs634537 was noted to have the strongest association. The genome-wide analysis suggested 129 genetic variants were associated with the risk. In line with existing evidence, this study suggested that glioma in children and AYA is associated with some, although not all, established adult glioma risk variants with risk.