Zhao Y, et al. - Given the reports of associating numerous genetic variants from meta-analyses of observational studies and GWAS with migraine susceptibility but with doubtful noteworthiness of the results showing statistically significant, researchers conducted this field synopsis and re-analysis study to estimate the noteworthiness using a Bayesian approach in hope of finding true associations. Searching PubMed, they included relevant meta-analyses from observational studies and GWAS examining the correlation between all genetic variants and migraine risk. Observational studies yielded 8 significant genetic variants; of these, none showed noteworthy at a prior probability of 0.001. In GWAS, 47 significant genetic variants were identified; of these, 36 were noteworthy at the prior probability of 0.000001 via false-positive rate probability or Bayesian false discovery probability. Further, the pathways “positive regulation of cytosolic calcium ion concentration” and “inositol phosphate-mediated signaling” were recognized and the relation of hub genes including MEF2D, TSPAN2, PHACTR1, TRPM8 and PRDM16 with migraine susceptibility was observed. These data seem to have implications for identification of novel genetic biomarkers and potential therapeutic target for migraine.