Xing Q, et al. - Researchers assessed the association of 2 tagging single nucleotide polymorphisms (SNPs) (rs1417080 and rs7859384) of lncARSR [(lncRNA Activated in RCC with Sunitinib Resistance, ENST00000424980); a newly identified long noncoding RNA to promote the sunitinib resistance of renal cell carcinoma (RCC), which may contribute to tumorigenesis and progression] with the risk and prognosis of RCC in a 2-stage case-control study. Findings revealed that rs7859384 of lncARSR was related to RCC susceptibility. Among individuals with body mass index > 24, without hypertension, without family history of cancer, SNP rs7859384 GA/GG genotypes had a protective impact. Higher survival rate was observed in subjects with GA/GG genotypes vs the corresponding AA wild genotypes in the dominant model. rs7859384 of lncARSR could serve as a prognostic biomarker for patients with RCC.