Yang SS, Wang Y, He Y, et al. - Using a large sample of Chinese people aged at least 50 years in southern China, researchers created and tested a body mass index (BMI) genetic risk score (GRS). At the age of 20 years old and at middle age, information about the weights of the participants was collected and used to test the BMI-GRS effect modes. The GRS was established using the participants ' genetic data from the Guangzhou Biobank Cohort Study and selected single nucleotide polymorphisms (SNPs) related to BMI. The study sample consisted of 13,597 candidates with 12 SNPs. At baseline and follow-up, high-GRS candidates had a higher likelihood of being overweight/obese, and this was a dose-response relationship. Metabolically unhealthy obese also correlated with the GRS.