Mishra V, et al. - Because of contradictory or inconclusive results obtained in several case-control studies and meta-analysis that have assessed the risk association of various SNPs with medullary thyroid carcinoma (MTC) in diverse populations, researchers performed a comprehensive risk association of 13 SNPs of three pathways—detoxification, cell cycle regulation and RET in an extensive cohort of 438 Indian MTC cases and 489 gender and ethnicity matched healthy controls from 1000 genome project. They also carried out a meta-analysis of RET SNPs. For the first time ever, a significant protective risk association of CDKN1ASer31Arg SNP with MTC was revealed in this largest SNP risk association research for MTC and the only risk association investigation of the 13 most commonly analyzed MTC related SNPs in a single cohort of this rare cancer. All four RET SNPs, ie, G691S, L769L, S836S, S904S, showed significant risk association; a finding by this present meta-analysis and not reported in the earlier meta-analysis.