Xiao X, et al. - Authors evaluated the distribution of risk alleles in an independent sample of Caucasian women and ascertained whether such genetic components were related to bone mineral density (BMD) variation in the sample. As per data, a high genetic risk of osteoporosis was seen in a substantially large percentage of healthy Caucasian women. Experts noted a significant association of weighted genetic risk scores (GRSs) with decreased BMD. A difference in the contribution of subtype GRS to the BMD variation by specific biological pathway and skeletal regions was seen.