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Genetic predisposition to type 2 diabetes and risk of subclinical atherosclerosis and cardiovascular diseases among 160,000 Chinese adults

Diabetes Aug 14, 2019

Gan W, Bragg F, Walters RG, et al. - Researchers studied how genetically-predicted type 2 diabetes is linked with cardiovascular diseases (CVD) among ∼160,000 candidates from the China Kadoorie Biobank to evaluate whether these associations are causal. A type 2 diabetes genetic risk score (including 48 established risk variants) was linked to the presence of carotid plaque, and elevated risk of ischemic stroke (IS), non-lacunar IS and major coronary event (n = 5,081). No significant association was found with lacunar IS or intracerebral hemorrhage, although the estimates of effects were not precise. According to findings, atherosclerotic CVD, consistent with a causal link, was related with a genetic predisposition to type 2 diabetes among Chinese adults.

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