Salvador-Martín S, Bossacoma F, Pujol-Muncunill G, et al. - An observational, longitudinal, ambispective cohort's study was carried out to identify genetic variants correlated with the long-term response to anti-tumor necrosis factor (TNF) drugs in children with inflammatory bowel disease (IBD). The authors selected 209 IBD-diagnosed anti-TNF treated children and genotyped 21 polymorphisms previously studied in adults with Crohn disease (CD) using real-time PCR. Using the log-rank test, the link between single-nucleotide polymorphisms (SNPs) and time-to-failure was analyzed. After multivariate analysis, 3 SNPs in IL10, IL17A and IL6 were significantly correlated with response to anti-TNF treatment among patients diagnosed with CD. Before starting treatment, genotyping of these DNA variants can help to identify children who are long-term responders to anti-TNF drugs, and thus tailor treatment of pediatric IBD.