Cooiman MI, Kleinendorst L, Aarts EO, et al. - A large bariatric cohort was examined for the prevalence of genetic obesity and was assessed for its effect on the response to bariatric surgery. Researchers performed a mutation analysis of 52 obesity-associated genes among 1,014 patients with BMI > 50 kg/m², an indication for revisional surgery or early onset of obesity (< 10 years of age). Of these, 30 (3%) were diagnosed with genetic obesity. Pathogenic heterozygous mutations in either MC4R, POMC, PCSK1, SIM1, or PTEN, were identified as the causative factors. Among these patients, no interference was observed of the clinical effects of heterozygous mutations in POMC and PCSK1 with the efficacy of most commonly performed bariatric procedures within the first 2 years of follow-up. Superior weight loss was reported among patients with MC4R mutations following primary Roux-en-Y gastric bypass compared with sleeve gastrectomy.