Yennurajalingam S, Astolfi A, Indio V, et al. - This study was attempted to ascertain the genetic factors associated with pain severity, daily opioid dose, and pain response in advanced cancer (AC) patients receiving supportive care. Logistic regression models and SKATO (Gene-block) analysis were used to evaluate pain phenotype. Researchers examined 174/178 (98%) patient samples. The result distinguished that SNPs of OPRM1, COMT, NFKBIA, CXCL8, IL-6, STAT6, and ARRB2 genes were correlated with pain severity, opioid daily dose, and pain response in AC receiving supportive care. Future studies are required to confirm findings for PPT.