Arthur RS, et al. - Among 146,326 women from the UK Biobank, researchers investigated the link of a modified healthy lifestyle index (HLI) with the risk of invasive breast cancer by genetic risk group, employing Cox proportional hazards regression models. They created an HLI score based on a combination of diet, physical activity, smoking, alcohol intake and anthropometry, and utilized 304 breast cancer-related genetic loci to generate a polygenic risk score (PRS). They observed 22% and 31% decreases in invasive breast cancer risk in relation to a favorable lifestyle (highest tertile) in premenopausal and postmenopausal women, respectively, while they found a link between a high PRS (highest tertile) and more than a doubling in the risk in both groups. Experts concluded that among women of European ancestry, the influence of genetic factors on invasive breast cancer risk may be attenuated by an overall healthy lifestyle.