Sun D, et al. - The roles of the genetic variation, methylation and gene expression at NFATC2IP locus in adiposity changes in a 2-year weight-loss trial was investigated. For this analysis, study participants were genotyped and randomly assigned to 1 of the 4 reduced-calorie diets, DNA methylation was derived from stored blood samples at baseline, and adipose tissue gene expression was measured in 96 volunteers. Researchers reported potentially causal effects of genetic, epigenetic and transcriptional variations at the NFATC2IP locus on adiposity changes in response to dietary fat intake.