Jia Q, et al. - Researchers investigated additional genetic determinants of circulating glycine levels as well as associations with coronary artery disease (CAD) and traditional risk factors in 30,118 subjects of European ancestry, by analyzing genome-wide association study data. They used Mendelian randomization and other analytical approaches and identified 12 loci which were significantly related to circulating glycine levels, among these, ACADM,PHGDH,COX18-ADAMTS3,PSPH,TRIB1,PTPRD, and ABO were not previously known to have implication in glycine metabolism. Directionally consistent links with decreased risk of CAD were individually shown by glycine-raising alleles at several loci, however, glycine did not directly account for these impacts because of links with other CAD-related traits. Overall, a causal link between circulating glycine levels and risk of CAD in humans was not conclusively evident in this study.