Mariani A, et al. - RNA sequencing of ovarian cancer (OC) primary tumors and their corresponding bowel metastases (n = 21 discovery set; n = 18 replication set) was done to recognize genes and pathways involved in promotion of metastasis to the bowel in high-grade serous OC. In addition, researchers evaluated how clinical outcomes are associated with these genes and pathways. The discovery set yielded 27 differentially expressed genes; of these, 21 were confirmed in the replication set: SFRP2, Col11A1, LRRC15, ADAM12, ADAMTS12, MFAP5, LUM, PLPP4, FAP, POSTN, GRP, MMP11, MMP13, C1QTNF3, EPYC, DIO2, KCNA1, NETO1, NTM, MYH13, and PVALB. They noted a necessity for complex bowel surgery and poor prognosis in correlation to high expression of these genes in primary OCs. Potential therapeutic targets of malignant bowel obstruction in OC could be identified with the help of these genes.