Xu T, et al. - This study was conducted in order to comparatively explore the gene expression profiles of primary and lymph node metastatic acral melanoma (AM) tissues. In contrast with the primary tumors, the expression levels of 396 genes were increased, and that of 766 genes were decreased in the metastatic tissues. Based on the yielded data, experts defined the gene expression signature of AM metastasis and illustrated that cell division cycle-associated 5 (CDCA5) served as a potential therapeutic target in AM.