Barrera-Reyes PK, et al. - Researchers analyzed changes in gene expression in peripheral mononuclear cells (PBMCs) in healthy young adults who consumed a single dose of high-polyphenols cocoa powder and maltodextrins as control, with a one-week washout period. Analysis of conjugated (-)-epicatechin metabolites in plasma, which may be related with an antioxidant response in healthy human, was also carried out. They found that there was no link between conjugated metabolites in plasma and antioxidant capacity. A sight variation was noted in the metabolites profile across subjects. They also observed that anti-inflammatory impacts were indicated by the observed changes in PBMCs gene expression. Inflammatory cytokines and other molecules involved in redox balance constituted differentially expressed genes.