You X, et al. - Researchers used the cBioPortal, Human Protein Atlas, and Oncomine databases, to investigate genetic alteration and mRNA expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) family in gastric cancer (GC) patients. They utilized “The Kaplan–Meier plotter” database to assess the prognostic value of distinct NOX in GC patients. mRNA deregulation of NOX genes was commonly detected. In GC patients, high mRNA expression of NOX2 was found to be related to better overall survival, while NOX4 and DUOX1 were associated with worse overall survival, specifically in intestinal-type GC patients. Overall, in GC, potential prognostic markers are individual NOX family genes, especially NOX2/4 and DUOX1. An effective strategy for GC therapy may be the use of NOX inhibitor targeting NOX4 and DUOX1.